🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsRetatrutide & Triple AgonistsTriple agonist side effect profile — my results so far Page 2

Triple agonist side effect profile — my results so far

lisa_labSD Fri, Jan 31, 2025 at 7:26 PM 30 replies 2,203 viewsPage 2 of 6
NurseKim_ATL
Senior Member
1,678
7,234
Feb 2024
Atlanta, GA
Feb 1, 2025 at 1:30 AM#6
Dr.BariatricHTX said:
It helps to say which part of this you are uncertain about.

I would rather people stopped quoting the 24% as if it were a licensed outcome. It is a phase 2 result in a few hundred participants with no cardiovascular endpoint and no long-term safety data, and this board has a habit of treating pipeline numbers as settled.

That is the short version; the long version is somebody else's post.

1 21denise_HTX
Reply Quote Save Share Report
Dr.GutHealth
Senior Member
1,456
7,890
Mar 2024
Minnesota
Feb 1, 2025 at 3:53 AM#7

The figures, for anyone assembling their own picture. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

I would rather be corrected than agreed with, if it comes to it.

50 20tyler_CSCS, VanRx_Mike, steve_okc and 47 others
Reply Quote Save Share Report
Dr.LeslieOBGYN
Member
567
2,567
May 2024
Dallas, TX
Feb 1, 2025 at 6:16 AM#8
NurseKim_ATL said:
I would rather people stopped quoting the 24% as if it were a licensed outcome.

Adding the part of the answer the thread has not reached. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

49 19james_edin, FranDenver, Dr.BariatricHTX and 46 others
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides

GL Biochem (Shanghai) Ltd. — Direct Manufacturer

Est. 1998. The synthesis house behind the vials you send for testing. ISO 9001 and cGMP certified, 1,500+ staff, batch-specific COA with every order.

Browse GL Biochem
zoe_NC
Member
278
1,234
Nov 2024
Charlotte, NC
Feb 1, 2025 at 8:39 AM#9

Following on from CarlaRPh_TPA — and this may be the naive question:

What the phase 2 dropout pattern implies about how the phase 3 tolerability will read?

48 18NicoleRaleigh, james_edin, FranDenver and 45 others
Reply Quote Save Share Report
lisa_labSD
Member
278
1,234
Oct 2024
San Diego, CA
Feb 1, 2025 at 8:06 PM#10

Closing the loop on my own question.

Rereading it with the dropout table open changed my view. I still think it is the most interesting molecule in the pipeline; I no longer think the 24% is the number that will end up on a label.

40 13cory_ATX, lori_vegas, Dr.PulmRoch and 37 others
Reply Quote Save Share Report

Similar Threads

TRIUMPH-3 topline results — 24.2% body weight loss at 48 weeks10 replies
Retatrutide mechanism: GLP-1/GIP/glucagon triple agonism explained5 replies
Retatrutide Phase 2 dose-response analysis — optimal dose range10 replies
Glucagon receptor agonism and hepatic lipid oxidation — MASH implications13 replies
Retatrutide vs tirzepatide — dual vs triple agonist comparison22 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register