🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersA1C from 7.2 to 5.1 — my results so far

A1C from 7.2 to 5.1 — my results so far

AttorneyGrant Mon, Jul 22, 2024 at 10:11 PM 58 replies 2,678 viewsPage 1 of 12
This thread is more than 22 months old. Information may be outdated. Consider searching for more recent discussions.
AttorneyGrant
Member
567
2,890
Apr 2024
Washington, DC
Jul 22, 2024 at 10:11 PM#1

A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

So the question, as narrowly as I can put it: why A1C lags the way it does, and what to look at in the meantime if you want to know sooner.

I have searched first, so if this is covered somewhere point me at it and I will read it.

41 11Dr.SleepRoch, laura_annarbor, JenMemphis and 38 others
Reply Quote Save Share Report
BenResearch_OR
Senior Member
2,456
11,234
Dec 2023
Oregon
Jul 23, 2024 at 12:25 AM#2
AttorneyGrant said:
A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone:

TestBaselineMonth 3Month 6Month 12
Glucose (fasting)1191019185
Insulin (fasting)2515115
HOMA-IR5.54.01.91.3
Uric Acid8.76.95.85.0

The insulin resistance improvement (HOMA-IR) is what my endo focuses on most. Going from 5.5 to near 1.0 is a metabolic transformation.

Last edited: Jul 23, 2024 at 1:25 AM
40 10PharmD_Rodriguez, julia.endo, JessicaM_2024 and 37 others
Reply Quote Save Share Report
NauseaFreeNow
Member
345
1,234
Aug 2024
Indiana
Jul 23, 2024 at 2:39 AM#3
BenResearch_OR said:
Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone: Test Baseline Month 3 Month 6 Month 12…

Insulin sensitivity test (HOMA-IR) on glycaemic control — arguably the most important metabolic marker most people aren't tracking:

HOMA-IR = (fasting insulin × fasting glucose) ÷ 405

My numbers: Baseline HOMA-IR = 5.1 (insulin resistant) → Current = 1.5 (insulin sensitive)

Anything above 2.0 indicates insulin resistance. The goal is below 1.5. GLP-1 agonists address the root metabolic dysfunction, not just the symptoms. This is why they work so much better than calorie restriction alone.

39 9Dr.PulmRoch, maya_sedona, stefan_berlin and 36 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
ChrisMacros
Member
567
2,345
Sep 2024
Michigan
Jul 23, 2024 at 4:53 AM#4
AttorneyGrant said:
A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

This matches mine closely enough to be worth saying so out loud. The detail I would add is minor and it is already implied above.

38 8LibrarianMeg, bri_stats, pete_manc_UK and 35 others
Reply Quote Save Share Report
DeniseRN_TPA
Member
345
1,567
Aug 2024
Tampa, FL
Jul 23, 2024 at 6:15 PM#5

Adding the clinical framing, because it changes how the question reads.

PCOS success story with glycaemic control: as someone with polycystic ovary syndrome, this medication has been transformative beyond weight loss.

After 7 months: periods became regular for the first time in years, testosterone levels normalized, acne cleared significantly, and — unexpectedly — I got pregnant naturally after 4 years of trying.

GLP-1 agonists address the insulin resistance at the root of PCOS. For PCOS patients, this isn't "just" a weight loss drug — it's treating our underlying metabolic dysfunction.

37 7Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 34 others
Reply Quote Save Share Report

Similar Threads

Optimal lab testing frequency on GLP-1 — evidence-based schedule5 replies
A1C from 7.2 to 5.1 — my bloodwork transformation19 replies
Thyroid function monitoring on GLP-1 — TSH and free T4 trends3 replies
Lipid panel improvements mega-thread — share your numbers19 replies
Liver enzymes trending down on GLP-1 — ALT/AST normalization17 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register