Forums›Lab Results & Biomarkers›Hormone panel changes — 6 month update

Hormone panel changes — 6 month update

Dr.PathRoch Fri, May 17, 2024 at 12:04 AM 16 replies 2,169 viewsPage 1 of 4

This thread is more than 25 months old. Information may be outdated. Consider searching for more recent discussions.

Dr.PathRoch

Member

456

2,123

Jun 2024

Rochester, MN

May 17, 2024 at 12:04 AM#1

Alright guys, I have to share this because I was not expecting it. I'm a 41-year-old male, started tirzepatide 9 months ago primarily for weight loss (SW: 278, CW: 218). My urologist had me on TRT (testosterone cypionate 100mg/week) for low T. My hormone panels are wild: | Marker | Pre-Tirz (on TRT) | 5 Mo (on TRT) | 9 Mo (OFF TRT 8 wks) | Ref Range | |--------|-------------------|---------------|---------------------|-----------| | Total T | 612 ng/dL | 824 ng/dL | 688 ng/dL | 264-916 | | Free T | 12.4 pg/mL | 18.2 pg/mL | 15.8 pg/mL | 8.7-25.1 | | SHBG | 18 nmol/L | 32 nmol/L | 38 nmol/L | 16-55 | | Estradiol | 48 pg/mL | 28 pg/mL | 22 pg/mL | 8-35 | | LH | <0.2 (suppressed on TRT) | <0.2 | 5.8 mIU/mL | 1.7-8.6 | | FSH | <0.5 (suppressed) | <0.5 | 4.2 mIU/mL | 1.5-12.4 | READ THAT AGAIN. I came OFF TRT 8 weeks ago and my total testosterone is 688 — HIGHER than it was ON TRT before weight loss. My LH and FSH recovered, meaning my hypothalamic-pituitary axis restarted. My urologist said the weight loss restored my endogenous testosterone production. He said obesity suppresses testosterone through multiple mechanisms and that dramatic fat loss can be "curative" for many cases of obesity-related hypogonadism. I haven't injected testosterone in 2 months and I feel BETTER than I did on TRT. This is life changing.

48 18MikeFit_NJ, InsuranceTom, WendyG_ATL and 45 others

Reply Quote Save Share Report

tane_welly

Member

234

1,123

Sep 2024

Wellington, NZ

May 17, 2024 at 12:10 AM#2

Dude. This is exactly what I needed to see. I'm 38, BMI 36, on TRT for 2 years. Total T was 248 before TRT. Always wondered if it was the weight causing the low T or if I genuinely had primary hypogonadism. How did your urologist determine it was safe to come off TRT? Did you taper or just stop?

Last edited: May 17, 2024 at 3:10 AM

47 17carl_compliance, DanielChem_CHI, marco_milano and 44 others

Reply Quote Save Share Report

BenResearch_OR

Senior Member

2,456

11,234

Dec 2023

Oregon

May 17, 2024 at 12:16 AM#3

He actually suggested trying because of how much weight I'd lost. We did a supervised discontinuation: - Stopped testosterone cypionate - Started enclomiphene 12.5mg for 4 weeks (to kickstart LH/FSH) - Checked labs at 4 weeks and 8 weeks - LH was already 3.2 at 4 weeks — clear sign of recovery - By 8 weeks, LH 5.8, total T 688 — we declared victory He said if my T had been below 350 at 8 weeks we would have resumed TRT. But it came roaring back. The key indicator is LH recovery — if LH comes back but T stays low, that suggests primary testicular failure. If LH recovers AND T rises, it was central/obesity-related suppression all along.

Last edited: May 17, 2024 at 1:16 AM

46 16Dr.NateNeph, PharmD_Rodriguez, julia.endo and 43 others

Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards

Dr.DermMIA

Member

456

2,123

May 2024

Miami, FL

May 17, 2024 at 12:22 AM#4

's experience is well-supported by the literature. Here's the physiology: Why obesity causes low testosterone: 1. Adipose tissue contains aromatase, which converts testosterone to estradiol → high estradiol suppresses LH via negative feedback → low T 2. Visceral fat produces inflammatory cytokines (TNF-alpha, IL-6) that directly suppress testicular Leydig cell function 3. Insulin resistance impairs SHBG production → more free T available for aromatization → vicious cycle 4. Leptin resistance in obesity disrupts GnRH pulsatility Why weight loss restores testosterone: - Less aromatase activity → less estradiol → disinhibition of LH - Improved insulin sensitivity → increased SHBG → appropriate binding - Reduced inflammation → restored Leydig cell function Studies show 15-20% body weight loss can increase total testosterone by 200-300 ng/dL in obese men. Dr.PathRoch lost 60 lbs (22% of body weight) — his results are right in the expected range. Important caveat: This applies to obesity-related (functional) hypogonadism. Men with true primary hypogonadism (Klinefelter's, testicular injury, etc.) will still need TRT regardless of weight loss.

45 15PeptideChemSF, A1cHero_PHX, Dr.RenalNash and 42 others

Reply Quote Save Share Report

kim_atl_prep

Member

312

1,345

Aug 2024

Atlanta, GA

May 17, 2024 at 12:51 AM#5

Can we talk about the female hormone changes too? I'm 36F, PCOS, on semaglutide 6 months. My changes are different but equally significant: | Marker | Baseline | Month 6 | Ref Range (Follicular) | |--------|----------|---------|----------------------| | Total Testosterone | 68 ng/dL | 38 ng/dL | 15-46 | | Free Testosterone | 8.2 pg/mL | 4.1 pg/mL | 0.5-4.6 | | DHEA-S | 428 µg/dL | 312 µg/dL | 65-380 | | SHBG | 22 nmol/L | 48 nmol/L | 18-114 | | Estradiol | 82 pg/mL | 54 pg/mL | 12-166 | | AMH | 8.2 ng/mL | 6.1 ng/mL | 1.0-10.0 | My testosterone normalized for the first time in years. My PCOS symptoms are dramatically better — less acne, less facial hair, and (TMI?) my periods are finally regular for the first time since I was 16. My RE says the insulin sensitization is addressing the root cause of my PCOS.

CompoundTalk

Hormone panel changes — 6 month update

Sigma-Aldrich — Research-Grade Standards

Similar Threads

Log In

Create Account

Activate Account