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Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersVitamin B12 monitoring — looking for input

Vitamin B12 monitoring — looking for input

Dr.Martinez Thu, Feb 22, 2024 at 2:11 PM 20 replies 2,393 viewsPage 1 of 4
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Dr.Martinez
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Feb 22, 2024 at 2:11 PM#1

Six months of eating roughly 1,100 calories a day and my ferritin has halved, which I did not connect to the intake until somebody pointed it out.

What I am after is which deficiencies actually show up when intake drops this far, and which are worth testing rather than supplementing blind.

If the honest answer is that nobody knows, that is a useful answer and I would rather have it.

34 4AttorneyGrant, DebRD_ATL, KristenIndy and 31 others
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BariatricNurseD
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Feb 22, 2024 at 2:20 PM#2
Dr.Martinez said:
Six months of eating roughly 1,100 calories a day and my ferritin has halved, which I did not connect to the intake until somebody pointed it out.

Vitamin D levels and micronutrients: an often-overlooked connection. Obese individuals store vitamin D in adipose tissue, making it less bioavailable. As you lose fat, vitamin D can actually increase WITHOUT supplementation.

My trajectory: Baseline 18 ng/mL → Month 6 (with supplement) 42 ng/mL → Month 12 48 ng/mL. Target is 40-60 ng/mL. Adequate vitamin D supports immune function, bone health, and mood — all relevant during weight loss.

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ChrisMacros
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Feb 22, 2024 at 2:29 PM#3
BariatricNurseD said:
Vitamin D levels and micronutrients: an often-overlooked connection.

Blood count monitoring for micronutrients: my doctor noticed my MCV (mean corpuscular volume) trending up at month 6: 88 → 97 fL. This flagged potential B12 or folate deficiency.

Sure enough, B12 had dropped from 620 to 340 pg/mL. Started B12 injections monthly and MCV normalized within 2 months. GLP-1 agonists can impair B12 absorption — this is a real clinical concern that deserves routine monitoring.

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mark_tokyo
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Feb 22, 2024 at 2:38 PM#4
Dr.Martinez said:
Six months of eating roughly 1,100 calories a day and my ferritin has halved, which I did not connect to the intake until somebody pointed it out.

Can confirm. Same sequence, different timescale. Nothing to add that would improve it.

Last edited: Feb 22, 2024 at 5:38 PM
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rachel_ABQ
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Feb 22, 2024 at 3:24 PM#5

Clinical perspective, offered as context rather than as advice.

Vitamin and mineral labs to check while on micronutrients — my doctor orders these quarterly:

  • B12: Can drop due to reduced GI absorption. Mine went from 650 to 380 — now supplementing.
  • Iron/Ferritin: Reduced food intake = reduced iron. Ferritin dropped from 64 to 31. Supplementing.
  • Vitamin D: Was already low (23 ng/mL), now taking 5000 IU daily.
  • Folate: Stable, no issues.
  • Zinc: Slightly low, added a multivitamin with zinc.

Nutritional deficiencies are a real risk when you're eating significantly less. Don't skip your labs!

30 0Dr.CardioMD, EndoResFellow, PharmacoVig_BOS and 27 others
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