PharmHunterJen said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

Ask again with the specifics and you will get a better answer than this one.

SaraMom3 said:

Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were…

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Taking it to my next appointment.

PharmHunterJen said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

Worth separating that from the pharmacology, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Adding the numbers, since they settle part of this. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Moderator note: the sourcing question belongs in the vendor section and has been split out. Tagging this one for the weekly digest.