Collecting this in one place because it comes up every few weeks and the answer is always assembled from scratch. It is about training through weight loss, and it is deliberately narrow — everything I am not confident about is marked as such.
Training does two things here and only one of them is on the scale. It protects lean mass — which is the reason to do it — and it contributes modestly to the deficit, which is the reason people start and then quit when the arithmetic disappoints them. In a deep deficit, resistance work is the priority and high-volume cardio competes with recovery.
The caveat that "exercise" for someone with mobility limitations is a different set of options, and the standard advice is written as though everyone can walk for an hour.
The narrow version of the question is what training is actually for during a large deficit, because framing it as calorie burn sets people up to quit when the arithmetic disappoints them. Numbers rather than impressions, if you have them.
mike.trainer_LA said:Training does two things here and only one of them is on the scale.
No disagreement with mike.trainer_LA. One condition attached. The meal advice is right and incomplete without the hydration point. People stop drinking because drinking makes them feel full, then attribute dehydration symptoms to the drug.
mike.trainer_LA said:Training does two things here and only one of them is on the scale.
I dislike how confidently this board tells people to push through. Incidence figures around 20 to 25% at the higher doses are class-typical, but the trials also had a discontinuation column, and "manageable with protocols" is not the same as manageable for everyone.
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Browse GL BiochemAnswering the narrow version, because the broad one does not have a single answer. The line between titrate-through and stop is not severity, it is trajectory and what else is present. Nausea that peaks and improves within a week is the expected pattern. Nausea that is escalating, or that comes with severe upper-abdominal pain radiating to the back, or that prevents fluids for more than a day, is a different conversation and belongs with a clinician the same day.
Ask again with the specifics and you will get a better answer than this one.
InsuranceTom said:The meal advice is right and incomplete without the hydration point.
Second this.