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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseDe novo lipogenesis reduction on GLP-1 — looking for input Page 6

De novo lipogenesis reduction on GLP-1 — looking for input

kate.chem Sat, Mar 28, 2026 at 11:30 AM 30 replies 896 viewsPage 6 of 6
SkepticalSean
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Mar 31, 2026 at 9:44 PM#26
DoseLogDan said:
Worth stating the units and the reference range whenever you post a number here.

I read this differently from DoseLogDan, on substance rather than tone. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

1 24DerekSJ_a1c
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MeganSA_TX
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Apr 1, 2026 at 6:31 AM#27
DoseLogDan said:
Worth stating the units and the reference range whenever you post a number here.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

2 0julia.endo, JessicaM_2024
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carl_compliance
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Apr 1, 2026 at 3:18 PM#28
DoseLogDan said:
Worth stating the units and the reference range whenever you post a number here.

That reframing is the part I needed.

Last edited: Apr 1, 2026 at 6:18 PM
3 1ricardo_MIA, BrianDallas92, labquiet_amy
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anna.melb_AU
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Apr 2, 2026 at 12:05 AM#29

Adding the clinical framing, because it changes how the question reads. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

4 2tammy_FL, Dr.LipidDallas, alex_tucson and 1 other
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kate.chem
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Apr 2, 2026 at 8:53 AM#30

Closing the loop on my own question.

Update, and it is the boring outcome: nothing was wrong. The measurement I was reading had moved less than its own week-to-week variation, which somebody said upthread and I did not believe.

26 24Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 23 others
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