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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseHas anyone dealt with alt normalization rates on glp-1? Page 3

Has anyone dealt with alt normalization rates on glp-1?

laura_annarbor Fri, Jan 9, 2026 at 9:24 PM 23 replies 1,414 viewsPage 3 of 5
DebRD_ATL
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Jan 12, 2026 at 5:54 PM#11
julia.endo said:
It helps to ask what evidence would change your mind before you look at any.

That is correct as far as it goes, and here is where it stops going. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

8 6BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 5 others
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CanadaChris
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Jan 13, 2026 at 5:58 AM#12
SleepDoc_PDX said:
Liver enzyme update related to liver and MASH: I had mildly elevated ALT/AST at baseline (likely NAFLD).

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Adding it to my notes with a link back to this thread.

9 7stefan_berlin, Dr.EM_Chicago, pete_RVA and 6 others
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nancy_portland
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Jan 13, 2026 at 6:02 PM#13
julia.endo said:
It helps to ask what evidence would change your mind before you look at any.

Pushing back on julia.endo here. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

10 8MarkLI_maint, Dr.PeteFamMed, claudia_zurich and 7 others
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VendorMark
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Jan 14, 2026 at 6:06 AM#14

The figures, for anyone assembling their own picture. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

11 9Dr.PeteFamMed, claudia_zurich, nancy_portland and 8 others
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mike_mod
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Jan 14, 2026 at 6:09 PM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. No action needed from anybody.

Last edited: Jan 14, 2026 at 8:09 PM
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