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ForumsSide Effects & ManagementInsomnia on semaglutide — circadian rhythm disruption or weight loss related? Page 2

Insomnia on semaglutide — circadian rhythm disruption or weight loss related?

Dr.SleepRoch Thu, May 7, 2026 at 12:08 AM 21 replies 761 viewsPage 2 of 5
claudia_zurich
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Jul 2024
Zurich, CH
May 7, 2026 at 5:53 AM#6

For anyone in a physically demanding role:

  • Start your medication on a stretch of days off if possible, so you can gauge your response
  • Don't under-eat. Set a caloric floor (1500+ for active jobs) and hit it even when not hungry
  • Frontload your calories — bigger breakfast before a shift, not a big dinner after
  • Electrolyte packets (LMNT, Liquid IV, etc.) during shifts
  • If fatigue is severe enough to impact patient safety or job performance, that's a conversation with your prescriber about dosing schedule or slower titration

The fatigue is almost always worst in the first 4-6 weeks and improves as your body adapts to both the drug and the new caloric baseline.

Last edited: May 7, 2026 at 11:53 AM
9 4emma_london, tammy_FL, Dr.LipidDallas and 6 others
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LibrarianMeg
Senior Member
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Mar 2024
Baltimore, MD
May 7, 2026 at 8:09 AM#7

One thing that's helped me enormously: strategic caffeine timing. I have coffee at 7am and green tea at 1pm. Not more, not later. Gives me two energy bumps without wrecking my sleep. And I eat a high-protein snack (Greek yogurt, handful of almonds, string cheese) between meals to prevent energy crashes. Small things but they add up.

8 3PharmD_Rodriguez, julia.endo, JessicaM_2024 and 5 others
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Dr.GastroMayo
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Jan 2024
Mayo Clinic, MN
May 7, 2026 at 10:24 AM#8

Okay, reality check received. I tracked everything carefully yesterday and I ate... 1,050 calories. I'm basically intermittent starving, not intermittent fasting. Going to make a conscious effort to hit 1,400 minimum starting today and get bloodwork done this week. Thank you all.

Last edited: May 7, 2026 at 3:24 PM
7 2COA_Karl, MikeFit_NJ, InsuranceTom and 4 others
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