🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementTMI but the constipation is REAL Page 2

TMI but the constipation is REAL

NauseaFreeNow Fri, Apr 17, 2026 at 1:00 PM 37 replies 1,223 viewsPage 2 of 8
Dr.NateNeph
VIP Member
2,987
16,234
Dec 2023
Houston, TX
Apr 17, 2026 at 4:10 PM#6
DebRD_ATL said:
Fiber trials in this population are thin, and most of what gets quoted is extrapolated from idiopathic constipation in people eating normally.

Worth saying plainly that not all of this is benign. Severe constipation on delayed gastric emptying has produced obstruction and ileus cases, rarely but genuinely. Pain with vomiting and no bowel movement is not a fiber conversation.

35 5JakeSmashed95, NauseaFreeNow, SteveThurs and 32 others
Reply Quote Save Share Report
stefan_berlin
Member
234
1,123
Oct 2024
Berlin, DE
Apr 17, 2026 at 5:24 PM#7
NauseaFreeNow said:
Constipation replaced nausea at around week five and has been the more persistent of the two by a wide margin.

Gastroparesis symptoms with constipation: the delayed gastric emptying from GLP-1 agonists can cause early satiety, bloating, and feeling "full" for hours after a small meal.

Tips: eat your protein FIRST (most important macro), then vegetables, then carbs last. Chew thoroughly — 20-30 chews per bite isn't excessive. Avoid carbonated beverages with meals. If symptoms are severe, your doctor may recommend a gastric emptying study.

34 4JessicaH_TX, KevinCompounds, TirzTom and 31 others
Reply Quote Save Share Report
Dr.PainCLE
Senior Member
1,234
6,234
Mar 2024
Cleveland, OH
Apr 17, 2026 at 6:38 PM#8
Dr.NateNeph said:
Worth saying plainly that not all of this is benign.

Drug interaction alert relevant to constipation: if you take oral levothyroxine (Synthroid), GLP-1 agonists can reduce absorption due to delayed gastric emptying. My TSH drifted up after starting semaglutide.

Solution: take levothyroxine on an empty stomach, 60 minutes before any food, and have your TSH rechecked 6-8 weeks after starting or changing GLP-1 dose. My endo had to increase my Synthroid by 12.5mcg.

33 3oliver_london, tane_welly, Dr.PathRoch and 30 others
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results
greg_boulder
Member
345
1,567
Jul 2024
Boulder, CO
Apr 17, 2026 at 7:52 PM#9

A narrower follow-up, since the general answer is now clear:

Whether fiber actually helps GLP-1 constipation or whether the evidence is borrowed from a different population?

32 2patPC_UT, Dr.DermMIA, fiona_VT and 29 others
Reply Quote Save Share Report
NauseaFreeNow
Member
345
1,234
Aug 2024
Indiana
Apr 18, 2026 at 1:47 AM#10

Closing the loop on my own question.

Resolved: water and magnesium first, soluble fibre second, bran gone entirely. Two months of doing it in the wrong order and a week to undo.

14 12cory_ATX, lori_vegas, Dr.PulmRoch and 11 others
Reply Quote Save Share Report

Similar Threads

Nausea incidence by dose tier — STEP and SURMOUNT meta-analysis16 replies
Constipation on GLP-1: pathophysiology and fiber protocol5 replies
Alopecia on GLP-1 — telogen effluvium differential diagnosis3 replies
Gallbladder disease risk — cholelithiasis data from clinical trials12 replies
Pancreatitis risk assessment — pooled safety analysis15 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register