🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementTMI but the constipation is REAL

TMI but the constipation is REAL

NauseaFreeNow Fri, Apr 17, 2026 at 1:00 PM 37 replies 1,223 viewsPage 1 of 8
NauseaFreeNow
Member
345
1,234
Aug 2024
Indiana
Apr 17, 2026 at 1:00 PM#1

Constipation replaced nausea at around week five and has been the more persistent of the two by a wide margin.

So the question, as narrowly as I can put it: what the mechanism is, because if it is transit rather than water then fiber is the wrong lever.

Practical detail welcome, however dull — the duller the better.

40 10stefan_berlin, Dr.EM_Chicago, pete_RVA and 37 others
Reply Quote Save Share Report
DebRD_ATL
Senior Member
1,678
7,890
Feb 2024
Atlanta, GA
Apr 17, 2026 at 1:14 PM#2

Taking the question as asked, rather than the general version of it. Fiber trials in this population are thin, and most of what gets quoted is extrapolated from idiopathic constipation in people eating normally. The extrapolation is not unreasonable but it is an extrapolation, and it fails specifically for insoluble fiber at low intake — the case that comes up here most often.

39 9RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 36 others
Reply Quote Save Share Report
nick_SD_fit
Member
278
1,234
Sep 2024
San Diego, CA
Apr 17, 2026 at 1:28 PM#3
DebRD_ATL said:
Fiber trials in this population are thin, and most of what gets quoted is extrapolated from idiopathic constipation in people eating normally.

Sulfur burps on constipation — the most underrated side effect nobody warned me about. 🤢 The smell is absolutely vile and comes on without warning.

What finally helped: eliminating eggs and cruciferous vegetables. Also, eating smaller portions and chewing thoroughly reduces the gas production.

If sulfur burps persist beyond 2-3 weeks, talk to your provider — it could indicate gastroparesis that needs medical attention.

38 8EndoResFellow, PharmacoVig_BOS, SurmountFan_IN and 35 others
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results
JakeSmashed95
Member
412
1,890
Aug 2024
Arkansas
Online
Apr 17, 2026 at 1:42 PM#4
NauseaFreeNow said:
Constipation replaced nausea at around week five and has been the more persistent of the two by a wide margin.

Same position here, arrived at the long way round. The mechanism is slowed transit plus reduced intake, and that combination determines which interventions work. Less food means less bulk, slower motility means more water reabsorbed, and the result is a smaller, drier, slower stool. Insoluble fiber adds bulk to a system that is already moving slowly, which is why it frequently makes things worse. Soluble fiber holds water and is the better first choice, and an osmotic agent works with the mechanism rather than against it.

I would rather be corrected than agreed with, if it comes to it.

37 7Dr.LipidDallas, alex_tucson, kevin_tulsa and 34 others
Reply Quote Save Share Report
GenomicsKate
Member
345
1,890
Oct 2024
Cambridge, MA
Apr 17, 2026 at 2:56 PM#5

From the other side of the consultation, briefly.

Acid reflux and constipation: I developed GERD symptoms around week 3 that I'd never had before. The delayed gastric emptying means food and acid sit in your stomach longer.

Management that works for me: elevate head of bed 6 inches, don't eat within 3 hours of lying down, avoid trigger foods (tomato, citrus, spicy, chocolate), and famotidine 20mg at bedtime. Much better now.

36 6claudia_zurich, nancy_portland, rick_sfbay and 33 others
Reply Quote Save Share Report
1238

Similar Threads

Nausea incidence by dose tier — STEP and SURMOUNT meta-analysis16 replies
Constipation on GLP-1: pathophysiology and fiber protocol5 replies
Alopecia on GLP-1 — telogen effluvium differential diagnosis3 replies
Gallbladder disease risk — cholelithiasis data from clinical trials12 replies
Pancreatitis risk assessment — pooled safety analysis15 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register