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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementTMI but the constipation is REAL Page 5

TMI but the constipation is REAL

NauseaFreeNow Fri, Apr 17, 2026 at 1:00 PM 37 replies 1,223 viewsPage 5 of 8
Dr.SportsMedIN
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Feb 2024
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Apr 19, 2026 at 3:21 AM#21

Following on from anna.melb_AU — and this may be the naive question:

What would you measure differently if you were starting again?

46 19lucas_SP_BR, lisa_labSD, adam_van and 43 others
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greg_boulder
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Jul 2024
Boulder, CO
Apr 19, 2026 at 10:23 AM#22
MarkLI_maint said:
The mechanism and the magnitude are separate questions.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

47 20fiona_VT, denise_HTX, raj_cambridge and 44 others
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mark_tokyo
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Apr 19, 2026 at 5:25 PM#23
MarkLI_maint said:
The mechanism and the magnitude are separate questions.

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

Last edited: Apr 19, 2026 at 8:25 PM
48 21LibrarianMeg, bri_stats, pete_manc_UK and 45 others
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sarah_TO
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Toronto, CA
Apr 20, 2026 at 12:27 AM#24
MarkLI_maint said:
The mechanism and the magnitude are separate questions.

This is exactly what I could not find anywhere else. Printing the relevant bit and taking it with me.

49 22carl_compliance, DanielChem_CHI, marco_milano and 46 others
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JenPlateau
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Nov 2024
Missouri
Apr 20, 2026 at 7:28 AM#25

From the other side of the consultation, briefly. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.

50 23sarah_nash92, FitDadDave, RunnerRach and 47 others
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