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Evidence-based GLP-1 & peptide discussion since 2023
ForumsExercise & Body CompositionDEXA scan longitudinal data — looking for input Page 4

DEXA scan longitudinal data — looking for input

AussieAnna Mon, Oct 20, 2025 at 5:51 AM 27 replies 1,475 viewsPage 4 of 6
GenomicsKate
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Oct 26, 2025 at 3:40 AM#16

From the other side of the consultation, briefly.

Physical therapist weighing in on lean mass. I work with bariatric and metabolic patients daily.

The resistance training evidence is critical here:

The Lundgren 2024 JAMA paper[1] showed that structured resistance training preserved 73% more lean mass in GLP-1 patients vs medication alone. When discussing lean mass, we MUST include the exercise component.

My minimum prescription: 3x/week compound movements (squat, deadlift, press, row), progressive overload, 7-10K steps/day, and 1.2-1.6g protein/kg/day.

References:
[1] Lundgren JR, et al. JAMA. 2024;331(1):38-48.
Last edited: Oct 26, 2025 at 8:40 AM
1 24DebRD_ATL
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sophie_paris
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Oct 26, 2025 at 11:22 PM#17
PharmacoVig_BOS said:
Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

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Dr.ObesityMed
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Oct 27, 2025 at 7:03 PM#18

Clinical perspective, offered as context rather than as advice.

DEXA scan update relevant to lean mass:

Scanned at months 0, 6, and 12. Here are the body comp numbers:

BaselineMonth 6Month 12
Total mass261 lbs216 lbs218 lbs
Fat mass121 lbs81 lbs53 lbs
Lean mass159 lbs152 lbs155 lbs
Body fat %38%32%22%

Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.6g/kg protein. The lean mass discussion needs to include body comp data, not just scale weight.

Last edited: Oct 28, 2025 at 1:03 AM
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FranDenver
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Oct 28, 2025 at 2:44 PM#19
Dr.ObesityMed said:
DEXA scan update relevant to lean mass: Scanned at months 0, 6, and 12.

Mine went the same way, slower.

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Admin
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Oct 29, 2025 at 10:25 AM#20

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here.

Last edited: Oct 29, 2025 at 2:25 PM
26 24PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 23 others
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