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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementMood changes on GLP-1 — need advice Page 2

Mood changes on GLP-1 — need advice

NurseAsh_DET Mon, Dec 15, 2025 at 9:28 PM 28 replies 1,107 viewsPage 2 of 6
NeuroNate
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Dec 16, 2025 at 4:11 AM#6
sarah.morrison said:
NurseAsh_DET said: ...mental health should only be used alongside therapy...

Pushing back on sarah.morrison here. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.

19 14jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 16 others
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Dr.PulmRoch
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Dec 16, 2025 at 6:49 AM#7
NurseAsh_DET said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

Therapy insights from my mental health journey: my therapist introduced me to the concept of "identity updating" — the psychological work of becoming a new version of yourself.

Key realizations: I used food to manage emotions, I had internalized fatphobia that I'm still unpacking, my social identity was partly built around being "the big guy/girl," and learning to accept compliments is surprisingly hard when you've been invisible for years.

Physical transformation without emotional processing is unstable. Do both.

18 13traveltech_sara, AttorneyGrant, DebRD_ATL and 15 others
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Dr.BariatricHTX
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Dec 16, 2025 at 9:27 AM#8
NeuroNate said:
I would be careful about how confidently the flatness reports get attributed.

Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 4. Not depression exactly, but a weird flatness. Food was my main coping mechanism and without that, I had to develop new ones.

Therapy has been essential. I'd strongly recommend anyone starting GLP-1 therapy also invest in mental health support. The physical transformation is only half the journey.

Last edited: Dec 16, 2025 at 3:27 PM
17 12Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 14 others
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patPC_UT
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Dec 16, 2025 at 12:05 PM#9

One thing that is still open after Dr.DermMIA’s answer:

Did your prescriber agree with that reading, and if not what was their objection?

16 11JessicaM_2024, TomFromTexas, mike.trainer_LA and 13 others
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NurseAsh_DET
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Dec 17, 2025 at 12:44 AM#10

Closing the loop on my own question.

Update: I got the sleep and the intake sorted before deciding it was the drug, and most of the flatness went with them. Not all of it, and I am watching the rest.

Last edited: Dec 17, 2025 at 6:44 AM
30 3emily_PDX, Dr.SleepRoch, laura_annarbor and 27 others
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