From the other side of the consultation, briefly. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.
Following on from TomTeleRx — and this may be the naive question:
What the dose-response curve actually looks like above 1.7mg, because the trial means hide how few people account for the extra loss?
Dr.MetabolicMD said:It helps to say which part of this you are uncertain about.
I read this differently from Dr.MetabolicMD, on substance rather than tone. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.
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Shop Reference StandardsDr.MetabolicMD said:It helps to say which part of this you are uncertain about.
Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.
Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Report rather than reply if it drifts again.