From the other side of the consultation, briefly. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

SarahChen_PharmD said:

Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent…

Same pattern here, and in the same order. I had assumed I was the exception until I read this.

SarahChen_PharmD said:

Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent…

Coming at SarahChen_PharmD’s question from a different direction. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

The figures, for anyone assembling their own picture. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

I would rather be corrected than agreed with, if it comes to it.

One thing that is still open after SarahChen_PharmD’s answer:

How much of the between-person variation is pharmacokinetic and how much is just adherence measured badly?