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ForumsProgress & Lab Results[PREMIUM] 18-month transformation — my results so far

[PREMIUM] 18-month transformation — my results so far

GenomicsKate Fri, Sep 26, 2025 at 8:48 AM 12 replies 1,282 viewsPage 1 of 3
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GenomicsKate
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Cambridge, MA
Sep 26, 2025 at 8:48 AM#1

Nine weeks flat after five months of steady loss, same dose, same routine, and I cannot tell whether to wait or change something.

What I am after is how to distinguish a genuine plateau from measurement noise and creeping intake, before changing anything.

Tell me what I have not thought of.

22 17DebRD_ATL, KristenIndy, MarkLI_maint and 19 others
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Dr.RenalNash
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Nashville, TN
Sep 26, 2025 at 10:50 AM#2
GenomicsKate said:
Nine weeks flat after five months of steady loss, same dose, same routine, and I cannot tell whether to wait or change something.

Plateau breaking story with a stall: I stalled at 216 lbs for 7 weeks. Tried everything — calorie cycling, increased exercise, more water. Nothing worked.

What finally broke the plateau: a brief dose increase followed by return to maintenance. Lost 8 lbs in the next 3 weeks. Plateaus are temporary — they always break if you stay consistent.

21 16pam_stl, wei_SG, cory_ATX and 18 others
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MikeNYC_runner
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New York, NY
Sep 26, 2025 at 12:52 PM#3
Dr.RenalNash said:
Plateau breaking story with a stall: I stalled at 216 lbs for 7 weeks.

That is correct as far as it goes, and here is where it stops going. Most reported plateaus are not plateaus. Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well inside the noise band. Before concluding anything, look at a rolling weekly average over at least four weeks and at a tape measure, because recomposition shows up in circumference before it shows up in weight. Then track intake honestly for a week: appetite suppression fades unevenly, and intake creeping back up is the single commonest cause.

20 15Dr.ObesityMed, HealthEcon_DC, PedsEndoPhilly and 17 others
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Dr.EndoEP
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Oct 2024
El Paso, TX
Sep 26, 2025 at 2:54 PM#4
GenomicsKate said:
Nine weeks flat after five months of steady loss, same dose, same routine, and I cannot tell whether to wait or change something.

Second this. Nothing to add that would improve it.

19 14Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 16 others
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claudia_zurich
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Zurich, CH
Sep 27, 2025 at 2:59 AM#5

Clinical perspective, offered as context rather than as advice. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

18 13kevin_tulsa, Dr.PainCLE, mike_mealprep and 15 others
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Amazing transformation! Starting at 287 lbs, I'm now at 162 lbs after 18 months on semaglutide 2.4mg/wk. These photos show my progress at months 3, 6, 9, 12, 15, and 18. The body recomposition has been incredible — DEXA shows 23% body fat, down from 42%...

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