PharmHunterJen said:

DerekSJ_a1c said: ...I stopped maintenance dosing and regained all the weight...

Can confirm. Same sequence, different timescale. Nothing to add that would improve it.

josh_phd_bmore said:

DerekSJ_a1c said: ...the STEP extension data on maintenance dosing is concerning...

Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.

Clinical perspective, offered as context rather than as advice.

STEP 5 long-term data on maintenance dosing: the 104-week (2-year) extension showed sustained weight loss of -15.2% with continued semaglutide vs weight regain in the discontinuation group[1].

Key insight: weight loss continued to accrue between weeks 68 and 104 in many patients, suggesting the nadir may not occur until year 2+. The 68-week primary endpoint in most trials may underestimate maximal efficacy.

This supports long-term, open-ended treatment rather than fixed-duration "courses" of therapy.

andrew_nyc said:

STEP 5 long-term data on maintenance dosing: the 104-week (2-year) extension showed sustained weight loss of -15.2% with continued semaglutide vs…

This is my experience too, for whatever a second data point is worth. The detail I would add is minor and it is already implied above.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Carry on.