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Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab ResultsHas anyone dealt with [premium] from morbid obesity to marathon finisher?

Has anyone dealt with [premium] from morbid obesity to marathon finisher?

mike.trainer_LA Wed, Sep 10, 2025 at 4:10 AM 26 replies 1,412 viewsPage 1 of 6
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mike.trainer_LA
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Sep 10, 2025 at 4:10 AM#1

Putting this up for argument rather than for agreement. I have read it twice and I am still not certain what it supports.

Most reported plateaus are not plateaus. Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well inside the noise band. Before concluding anything, look at a rolling weekly average over at least four weeks and at a tape measure, because recomposition shows up in circumference before it shows up in weight. Then track intake honestly for a week: appetite suppression fades unevenly, and intake creeping back up is the single commonest cause.

Where I think it is weakest: the population was selected and supported in ways a real cohort is not, so I would read the effect size as a ceiling rather than an expectation.

So the question, as narrowly as I can put it: how to distinguish a genuine plateau from measurement noise and creeping intake, before changing anything. If the honest answer is that nobody knows, that is a useful answer and I would rather have it.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
24 19Dr.AddMedPHL, newstart_MO, mia_MS2 and 21 others
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BethLabQueen
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Sep 10, 2025 at 4:19 AM#2
mike.trainer_LA said:
Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well…

Plateau breaking story with a stall: I stalled at 219 lbs for 6 weeks. Tried everything — calorie cycling, increased exercise, more water. Nothing worked.

What finally broke the plateau: increasing protein to 150g/day. Lost 9 lbs in the next 2 weeks. Plateaus are temporary — they always break if you stay consistent.

23 18Dr.PulmRoch, maya_sedona, stefan_berlin and 20 others
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VendorMark
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Sep 10, 2025 at 4:28 AM#3
mike.trainer_LA said:
Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well…

I read this differently from mike.trainer_LA, on substance rather than tone. The "it is your intake" reflex here gets tiring. Some people genuinely stop responding at a dose that worked, and telling them to track harder when they have already tracked is how people stop posting.

Last edited: Sep 10, 2025 at 6:28 AM
22 17MarkLI_maint, Dr.PeteFamMed, claudia_zurich and 19 others
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PharmacoVig_BOS
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Sep 10, 2025 at 4:37 AM#4

Answering the narrow version, because the broad one does not have a single answer. Genuine plateaus happen too, and the mechanism is metabolic adaptation plus a smaller body. A body 20kg lighter needs meaningfully fewer calories at rest and less to move, so the deficit that produced the first phase is arithmetically smaller now. The options are the honest ones — increase the deficit slightly, increase activity, or accept the new plateau — and escalating the dose is only one of them.

21 16kate.chem, DataDave, Dr.GutHealth and 18 others
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hyun_seoul
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Sep 10, 2025 at 5:25 AM#5
BethLabQueen said:
Plateau breaking story with a stall: I stalled at 219 lbs for 6 weeks.

Same pattern here, and in the same order. Nothing to add that would improve it.

Last edited: Sep 10, 2025 at 9:25 AM
20 15LipidDoc_ATL, BariatricNurseD, MASHdoc_SA and 17 others
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