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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseHas anyone dealt with mash biomarker panel? Page 2

Has anyone dealt with mash biomarker panel?

Dr.ObesityMed Mon, Jul 22, 2024 at 9:09 PM 27 replies 2,236 viewsPage 2 of 6
NurseKim_ATL
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Jul 23, 2024 at 8:11 PM#6
LabKate said:
Quarterly for the first year is convention rather than evidence, and it is defensible for a simple reason: it is roughly the interval over which HbA1c…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would drop the "get everything" instinct further than this thread does. Every extra test is another chance at a false positive, and incidental findings have their own cost in scans, biopsies and worry.

48 18denise_HTX, raj_cambridge, ingrid_STO and 45 others
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PharmacoVig_BOS
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Jul 24, 2024 at 5:21 AM#7

One concrete data point for the thread. Post reference ranges alongside numbers when you share them. Units differ by country — glucose and lipids especially — and half the confusion in these threads is unit mismatch rather than disagreement.

47 17Dr.GutHealth, amsterdam_pete, LondonLisa and 44 others
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SleepDoc_PDX
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Jul 24, 2024 at 2:31 PM#8
NurseKim_ATL said:
I would drop the "get everything" instinct further than this thread does.

Coming at NurseKim_ATL’s question from a different direction. A defensible baseline is short: HbA1c and fasting glucose, a lipid panel with ApoB if you can get it, ALT and AST, creatinine with eGFR, TSH, ferritin and B12, and a full blood count. That set catches the things that change, the things that explain symptoms, and the things that alter the prescribing decision. Almost everything else on the long circulating lists is either invariant, uninterpretable without a specific question, or an incidental finding waiting to cause an unnecessary workup.

Worth separating that from the baseline and follow-up panel, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

46 16carlos_SATX, sophie_paris, mel_PDX and 43 others
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Dr.DermMIA
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Jul 24, 2024 at 11:41 PM#9

Following on from rachel_ABQ — and this may be the naive question:

What actually belongs on a baseline panel, as opposed to the enormous list that gets pasted around here?

Last edited: Jul 25, 2024 at 1:41 AM
45 15PeptideChemSF, A1cHero_PHX, Dr.RenalNash and 42 others
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Dr.ObesityMed
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Jul 26, 2024 at 7:44 PM#10

Reporting back.

Took the whole panel in rather than the one flagged line, and the conversation lasted two minutes instead of generating three more tests.

31 4A1cHero_PHX, Dr.RenalNash, LipidDoc_ATL and 28 others
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