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ForumsMASH / Liver DiseaseHas anyone dealt with mash biomarker panel? Page 4

Has anyone dealt with mash biomarker panel?

Dr.ObesityMed Mon, Jul 22, 2024 at 9:09 PM 27 replies 2,236 viewsPage 4 of 6
Dr.PainCLE
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Jul 31, 2024 at 9:15 AM#16

From the other side of the consultation, briefly.

Liver imaging follow-up for liver and MASH: FibroScan at baseline showed CAP score 332 dB/m (moderate steatosis) and stiffness 10.8 kPa (possible fibrosis). Diagnosed with NAFLD.

After 12 months: CAP dropped to 235 dB/m (minimal steatosis) and stiffness normalized to 5.3 kPa. Hepatologist says the liver is essentially healing itself as the metabolic stress resolves.

GLP-1 agonists may become first-line NASH therapy. The Phase 3 data on semaglutide for NASH is very promising.

37 10Dr.PathRoch, mona_PHX, andrew_nyc and 34 others
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MikeFit_NJ
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Aug 1, 2024 at 3:29 AM#17
Dr.PainCLE said:
Liver imaging follow-up for liver and MASH: FibroScan at baseline showed CAP score 332 dB/m (moderate steatosis) and stiffness 10.8 kPa (possible…

Second this.

38 11marcus_mpls, DeniseRN_TPA, SandraNC_45 and 35 others
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hans_munich
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Aug 1, 2024 at 9:42 PM#18
Dr.PainCLE said:
Liver imaging follow-up for liver and MASH: FibroScan at baseline showed CAP score 332 dB/m (moderate steatosis) and stiffness 10.8 kPa (possible…

Adding the part of the answer the thread has not reached. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

Last edited: Aug 2, 2024 at 3:42 AM
39 12Dr.LipidDallas, alex_tucson, kevin_tulsa and 36 others
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Dr.AddMedPHL
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Aug 2, 2024 at 3:55 PM#19

Adding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

40 13TomFromTexas, mike.trainer_LA, sarah_nash92 and 37 others
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Admin
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Aug 3, 2024 at 10:08 AM#20

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Thread quality here is what the rules are for. Keep it up.

12 10PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 9 others
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