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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCOA & Analytical TestingHas anyone dealt with moisture content analysis for lyophilized peptides? Page 4

Has anyone dealt with moisture content analysis for lyophilized peptides?

zoe_NC Mon, Oct 20, 2025 at 10:26 AM 31 replies 1,698 viewsPage 4 of 7
NurseLeah_Nash
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Sep 2024
Nashville, TN
Nov 4, 2025 at 7:01 AM#16

Adding the clinical framing, because it changes how the question reads.

My vendor review relevant to certificates of analysis: ordered 3 times from my current compounder. Consistency has been excellent.

Shipping: Next-day with cold pack
Packaging: Professional, discreet, proper labeling with lot/batch numbers
Purity: 99.0% average across orders (Janoshik verified)
Customer service: Responsive within 2 hours
Price: $136/month for semaglutide 1.7mg equivalent

15 15RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 12 others
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BenResearch_OR
Senior Member
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Dec 2023
Oregon
Nov 6, 2025 at 3:43 PM#17
DoseLogDan said:
Mass spectrometry confirmation for certificates of analysis: beyond HPLC purity, mass spec tells you the molecule's exact molecular weight.

Thank you for spelling out the reasoning rather than just the conclusion. Taking it to my next appointment.

Last edited: Nov 6, 2025 at 4:43 PM
14 14PharmD_Rodriguez, julia.endo, JessicaM_2024 and 11 others
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Dr.GutHealth
Senior Member
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Minnesota
Nov 9, 2025 at 12:26 AM#18

From the other side of the consultation, briefly.

Community-verified vendors for certificates of analysis: I maintain a spreadsheet of Janoshik-verified test results submitted by community members. Across 60 submitted tests:

  • 85% tested at ≥98% purity
  • 10% tested at 95-98% purity
  • 5% tested at <95% purity (concerning)

The vendors with consistently high purity results are listed in the Vendor Directory. We update monthly based on new community submissions.

13 13jennifer_SEA, tyler_CSCS, VanRx_Mike and 10 others
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Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
ingrid_STO
Member
345
1,456
Jul 2024
Stockholm, SE
Nov 11, 2025 at 9:10 AM#19
Dr.GutHealth said:
Community-verified vendors for certificates of analysis: I maintain a spreadsheet of Janoshik-verified test results submitted by community members.

Second this. Nothing to add that would improve it.

12 12InsuranceTom, WendyG_ATL, SaraMom3 and 9 others
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Admin
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Oct 2023
Online
Nov 13, 2025 at 5:55 PM#20

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Carry on.

40 15PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 37 others
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