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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCOA & Analytical TestingHas anyone dealt with moisture content analysis for lyophilized peptides? Page 5

Has anyone dealt with moisture content analysis for lyophilized peptides?

newstart_MO Thu, May 30, 2024 at 8:42 AM 54 replies 2,788 viewsPage 5 of 11
sarah.morrison
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Jun 29, 2024 at 11:30 PM#21
MariaRD said:
Third-party testing services for certificates of analysis besides Janoshik: Janoshik: Gold standard for peptide community, ~$144, 10-14 day turnaround…

Adding a me-too, because a thread of one person's experience is not much use. I had assumed I was the exception until I read this.

Last edited: Jun 30, 2024 at 12:30 AM
9 7josh_phd_bmore, roxy_nash, tony_orlando and 6 others
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oliver_london
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Jul 11, 2024 at 8:02 PM#22
MariaRD said:
Third-party testing services for certificates of analysis besides Janoshik: Janoshik: Gold standard for peptide community, ~$144, 10-14 day turnaround…

Community-verified vendors for certificates of analysis: I maintain a spreadsheet of Janoshik-verified test results submitted by community members. Across 56 submitted tests:

  • 85% tested at ≥98% purity
  • 10% tested at 95-98% purity
  • 5% tested at <95% purity (concerning)

The vendors with consistently high purity results are listed in the Vendor Directory. We update monthly based on new community submissions.

10 8MikeNYC_runner and 7 others
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SleepDoc_PDX
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Jul 23, 2024 at 4:27 PM#23

One concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

11 9carlos_SATX, sophie_paris, mel_PDX and 8 others
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Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
Admin
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Aug 4, 2024 at 12:45 PM#24

A narrower follow-up, since the general answer is now clear:

Did your prescriber agree with that reading, and if not what was their objection?

12 10BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 9 others
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DataDave
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Aug 16, 2024 at 8:57 AM#25
SleepDoc_PDX said:
Say what you would expect to see if you were wrong, before you look.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

13 11Dr.GutHealth, amsterdam_pete, LondonLisa and 10 others
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