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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesGLP-1 and gluconeogenesis — what worked for you? Page 5

GLP-1 and gluconeogenesis — what worked for you?

matt_MKE Mon, Oct 20, 2025 at 10:35 AM 50 replies 1,666 viewsPage 5 of 10
cory_ATX
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Nov 7, 2025 at 7:55 PM#21
Dr.RaviCardio said:
Start from the measurement rather than the conclusion.

Coming at Dr.RaviCardio’s question from a different direction. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

10 8Dr.EndoEP, GraceAZ_72, carl_compliance and 7 others
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DoseLogDan
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Feb 2025
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Nov 14, 2025 at 3:20 PM#22

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

That is the short version; the long version is somebody else's post.

Last edited: Nov 14, 2025 at 4:20 PM
11 9Dr.AddMedPHL, newstart_MO, mia_MS2 and 8 others
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LarryQC_SD
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Nov 21, 2025 at 10:41 AM#23

A narrower follow-up, since the general answer is now clear:

What would you measure differently if you were starting again?

12 10TinaHashiRN, robert_kc, dan_philly and 9 others
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nick_newbie
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Nov 28, 2025 at 5:58 AM#24
DoseLogDan said:
If you are going to change something, change one thing and give it long enough to express itself.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

Last edited: Nov 28, 2025 at 8:58 AM
13 11LarryQC_SD, wanda_boise, NurseAsh_DET and 10 others
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Dr.LeslieOBGYN
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May 2024
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Dec 5, 2025 at 1:10 AM#25
DoseLogDan said:
If you are going to change something, change one thing and give it long enough to express itself.

True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.

14 12mike_mealprep, NicoleRaleigh, james_edin and 11 others
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