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ForumsMetabolic Health & DiabetesGLP-1 and gluconeogenesis — what worked for you? Page 8

GLP-1 and gluconeogenesis — what worked for you?

matt_MKE Mon, Oct 20, 2025 at 10:35 AM 50 replies 1,666 viewsPage 8 of 10
ben_calgary
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Calgary, CA
Feb 17, 2026 at 7:58 AM#36
Dr.CardioMD said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Mine went the same way, slower. I had assumed I was the exception until I read this.

Last edited: Feb 17, 2026 at 1:58 PM
46 19KetoKyle, CanadaChris, ZaraB_AL and 43 others
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JenMemphis
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Jan 2025
Memphis, TN
Feb 24, 2026 at 1:02 AM#37
Dr.CardioMD said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

There is a second half to this that has not been said yet. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

47 20BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 44 others
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dave_SLC
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Salt Lake City, UT
Mar 2, 2026 at 6:01 PM#38

The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Last edited: Mar 2, 2026 at 10:01 PM
48 21james_edin, FranDenver, Dr.BariatricHTX and 45 others
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Dr.PainCLE
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Mar 2024
Cleveland, OH
Mar 9, 2026 at 10:57 AM#39

Following on from Dr.CardioMD — and this may be the naive question:

Was that from a primary source or from a summary of one?

49 22bbq_ray_KC, oliver_london, tane_welly and 46 others
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robert_kc
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Oct 2024
Kansas City, MO
Mar 16, 2026 at 3:49 AM#40
dave_SLC said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

21 19PharmHunterJen, TomTeleRx, DoseLogDan and 18 others
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