Clinical perspective, offered as context rather than as advice. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

Worth separating that from glycaemic control, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

anders_CPH said:

Shot day Friday report relevant to baseline bloodwork: Week 22.

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

anders_CPH said:

Shot day Friday report relevant to baseline bloodwork: Week 22.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Sending this to two other people who asked me the same thing last week.

From the other side of the consultation, briefly. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.