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ForumsLab Results & BiomarkersCortisol and GLP-1 — HPA axis during caloric deficit Page 2

Cortisol and GLP-1 — HPA axis during caloric deficit

Dr.ReproEndo Sun, May 17, 2026 at 2:46 AM 16 replies 540 viewsPage 2 of 4
BiostatsBrad
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May 17, 2026 at 6:13 AM#6

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

34 12LindaRN_retired, tommy_boulder, hyun_seoul and 31 others
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JenMemphis
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May 17, 2026 at 7:34 AM#7

A narrower follow-up, since the general answer is now clear:

How long did you give it before you decided it was working?

35 13BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 32 others
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Dr.NutriCornell
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May 17, 2026 at 8:55 AM#8
BiostatsBrad said:
If you are going to change something, change one thing and give it long enough to express itself.

There is a second half to this that has not been said yet. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

36 14laura_annarbor, JenMemphis, pat_auckland and 33 others
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Dr.ReproEndo
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May 17, 2026 at 10:16 AM#9

Reporting back.

Late follow-up. I did not do what was suggested, I did something adjacent, and it worked; posting the difference in case it matters to somebody.

Last edited: May 17, 2026 at 11:16 AM
37 15GraceAZ_72, carl_compliance, DanielChem_CHI and 34 others
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kim_atl_prep
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May 17, 2026 at 4:44 PM#10
Dr.NutriCornell said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

That is correct as far as it goes, and here is where it stops going. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

15 15PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 12 others
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