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Evidence-based GLP-1 & peptide discussion since 2023
ForumsRetatrutide & Triple AgonistsWill reta make sema and tirz obsolete? Page 5

Will reta make sema and tirz obsolete?

andrew_nyc Sun, Apr 5, 2026 at 9:23 AM 33 replies 1,028 viewsPage 5 of 7
PedsEndoPhilly
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Apr 15, 2026 at 10:32 AM#21

Following on from PharmHunterJen — and this may be the naive question:

Did your prescriber agree with that reading, and if not what was their objection?

38 11sarah_TO, wendy_avl, jason_paloalto and 35 others
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SleepFixSam
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Apr 18, 2026 at 11:42 PM#22
SarahChen_PharmD said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

I read this differently from SarahChen_PharmD, on substance rather than tone. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

39 12ingrid_STO, pete_nash, hank_denver and 36 others
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RegAffairsDC
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Apr 22, 2026 at 12:49 PM#23
SarahChen_PharmD said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

40 13hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 37 others
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PurityPaulOR
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Apr 26, 2026 at 1:53 AM#24
SarahChen_PharmD said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

This is exactly what I could not find anywhere else. Adding it to my notes with a link back to this thread.

41 14Dr.Martinez, mike_mod, SarahChen_PharmD and 38 others
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SleepDoc_PDX
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Apr 29, 2026 at 2:56 PM#25

Clinical perspective, offered as context rather than as advice. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

Last edited: Apr 29, 2026 at 5:56 PM
42 15mel_PDX, Dr.AddMedPHL, newstart_MO and 39 others
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