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ForumsCardiovascular OutcomesLp(a) on GLP-1 agonists — anyone have experience? Page 2

Lp(a) on GLP-1 agonists — anyone have experience?

CryptoCarl Sun, Aug 4, 2024 at 1:09 PM 9 replies 1,886 viewsPage 2 of 2
TrialTracker_MD
Senior Member
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Jan 2024
Maryland
Aug 4, 2024 at 3:38 PM#6
Dr.RenalNash said:
Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data: Category Marker Before After…

Careful with treating an unchanged LDL-C as a failure. If ApoB and triglycerides both fell, the particle picture improved regardless of what the calculated LDL says.

I would rather be corrected than agreed with, if it comes to it.

27 22Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 24 others
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jason_paloalto
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Nov 2024
Palo Alto, CA
Aug 4, 2024 at 4:36 PM#7
CryptoCarl said:
Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been…

Comprehensive lipid panel update relevant to the lipid panel:

MarkerBaseline6 Months12 MonthsReference
Total Cholesterol244209189<200
LDL159129109<100
HDL424766>40
Triglycerides264159109<150
LDL-P14641114864<1000

The triglyceride drop is the most impressive. My cardiologist reduced my statin dose based on these results.

26 21Dr.PathRoch, mona_PHX, andrew_nyc and 23 others
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CarlaRPh_TPA
Senior Member
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Jan 2024
Tampa, FL
Aug 4, 2024 at 5:34 PM#8
TrialTracker_MD said:
Careful with treating an unchanged LDL-C as a failure.

Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel:

MarkerBaselineMonth 8Clinical Meaning
LDL-P1685985Particle count (more precise than LDL-C)
Small dense LDL55%33%Atherogenic pattern
Remnant cholesterol4114Triglyceride-rich lipoproteins
oxLDL7043Oxidative stress marker

The shift from small dense to large buoyant LDL is particularly important — it represents a fundamental change in the atherogenic profile.

25 20BrianDallas92, labquiet_amy, emily_PDX and 22 others
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gary_naperville
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Oct 2024
Naperville, IL
Aug 4, 2024 at 6:32 PM#9

Following on from TrialNerd_Beth — and this may be the naive question:

How long did you give it before you decided it was working?

24 19PharmHunterJen, TomTeleRx, DoseLogDan and 21 others
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CryptoCarl
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May 2024
Arizona
Aug 4, 2024 at 11:11 PM#10

OP back with an update, since a thread like this is useless without one.

Late follow-up. I did not do what was suggested, I did something adjacent, and it worked; posting the difference in case it matters to somebody.

34 7ChrisMacros, KetoKyle, CanadaChris and 31 others
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