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ForumsRetatrutide & Triple AgonistsRetatrutide Phase 2 dose-response analysis — need advice Page 5

Retatrutide Phase 2 dose-response analysis — need advice

SarahChen_PharmD Wed, Sep 11, 2024 at 8:40 PM 55 replies 2,123 viewsPage 5 of 11
JenMemphis
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Sep 13, 2024 at 8:36 PM#21
greg_boulder said:
True, and it depends on a baseline nobody has stated.

Mine went the same way, slower.

9 7MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 6 others
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jennifer_SEA
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Sep 14, 2024 at 7:52 AM#22
greg_boulder said:
True, and it depends on a baseline nobody has stated.

Adding the part of the answer the thread has not reached. Relative and absolute effects need reading together. A 20% relative reduction on a high baseline risk is a large absolute benefit; the same relative figure on a low baseline risk is a small one, and press summaries almost always quote the relative number because it is bigger.

10 8Dr.ReproEndo, lucas_SP_BR, lisa_labSD and 7 others
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dan_philly
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Sep 14, 2024 at 7:08 PM#23

The figures, for anyone assembling their own picture. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Happy to go further on any of that.

Last edited: Sep 14, 2024 at 10:08 PM
11 9SkepticalSean, Dr.CardioMD, EndoResFellow and 8 others
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VendorMark
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Sep 15, 2024 at 6:24 AM#24

A narrower follow-up, since the general answer is now clear:

How to read a result like this without either dismissing it or over-reading it, since the summaries all read like press releases?

12 10Dr.PeteFamMed, claudia_zurich, nancy_portland and 9 others
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Dr.PathRoch
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Sep 15, 2024 at 5:40 PM#25
dan_philly said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

Last edited: Sep 15, 2024 at 11:40 PM
13 11Dr.MetabolicMD, RetaRick_CA, JenPlateau and 10 others
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