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ForumsSemaglutide (Ozempic / Wegovy)Semaglutide and MASH — liver histology improvement data Page 4

Semaglutide and MASH — liver histology improvement data

MASHdoc_SA Wed, Jun 3, 2026 at 8:46 AM 22 replies 524 viewsPage 4 of 5
pat_auckland
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Jun 4, 2026 at 4:10 PM#16
carl_compliance said:
MASHdoc_SA said: ...but the FDA says semaglutide...

Agreed, and ALT falling is not the same as fibrosis improving. Enzymes are a crude proxy; FIB-4 or elastography is what tells you about the thing that matters.

Last edited: Jun 4, 2026 at 8:10 PM
31 4NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 28 others
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BenResearch_OR
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Jun 4, 2026 at 8:13 PM#17
FDA_TrackerJim said:
With resmetirom now available for MASH, combination approaches are being explored, so the standard of care in this area is moving faster than most…

This answered a question I did not know how to ask. Adding it to my notes with a link back to this thread.

32 5PharmD_Rodriguez, julia.endo, JessicaM_2024 and 29 others
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Dr.NephBHM_UK
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Jun 5, 2026 at 12:16 AM#18

Adding the clinical framing, because it changes how the question reads. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

33 6PharmacoVig_BOS, SurmountFan_IN, PeptideChemSF and 30 others
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mia_MS2
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Jun 5, 2026 at 4:19 AM#19
Dr.NephBHM_UK said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

Can confirm. Same sequence, different timescale.

34 7steve_okc, dave_SLC, FDA_TrackerJim and 31 others
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Admin
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Jun 5, 2026 at 8:22 AM#20

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Tagging this one for the weekly digest.

Last edited: Jun 5, 2026 at 12:22 PM
6 4PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 3 others
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