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ForumsExercise & Body CompositionCreatine kinase elevations on GLP-1 — what worked for you? Page 2

Creatine kinase elevations on GLP-1 — what worked for you?

A1cHero_PHX Thu, Apr 2, 2026 at 5:38 AM 37 replies 1,327 viewsPage 2 of 8
NurseKim_ATL
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Apr 2, 2026 at 6:58 AM#6
Dr.MetabolicMD said:
The intervention that works is boring and well evidenced: resistance training two to three times a week at a genuine effort, protein at 1.4 to 2.0…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I think this board over-worries about lean mass. Some lean loss is obligatory — you need less muscle to move a smaller body, and preserving mass you no longer need is not a health outcome. The question is whether strength and function held, and mine did.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

14 9denise_HTX, raj_cambridge, ingrid_STO and 11 others
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anders_CPH
Senior Member
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Feb 2024
Copenhagen, DK
Apr 2, 2026 at 7:29 AM#7
A1cHero_PHX said:
I lifted three times a week throughout and still lost lean mass.

My endo's protocol for lean mass plateau: if weight loss stalls for 6+ weeks at current dose, we go through this checklist before titrating up:

  1. Food diary review — is intake creeping up?
  2. Protein check — minimum 100g/day
  3. Activity audit — steps + resistance training
  4. Sleep quality — poor sleep kills GLP-1 efficacy
  5. Stress/cortisol management

Only after addressing all of these do we increase the dose. Often fixing one lifestyle factor restarts progress without needing more medication.

13 8MariaRD, AussieAnna, BethLabQueen and 10 others
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MASHdoc_SA
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Aug 2024
San Antonio, TX
Apr 2, 2026 at 8:00 AM#8
NurseKim_ATL said:
I think this board over-worries about lean mass.

OMG yes. lean mass + resistance training is the combo. Can confirm.

12 7JennaRN, LabKate, kate.chem and 9 others
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patPC_UT
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Park City, UT
Apr 2, 2026 at 8:31 AM#9

A narrower follow-up, since the general answer is now clear:

Whether resistance training and protein change the ratio or only the absolute amount?

11 6JessicaM_2024, TomFromTexas, mike.trainer_LA and 8 others
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A1cHero_PHX
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Phoenix, AZ
Apr 2, 2026 at 11:00 AM#10

Closing the loop on my own question.

Follow-up: I dropped the cardio to two easy sessions and put the effort into three real lifting sessions. The scale slowed and the scan improved.

Last edited: Apr 2, 2026 at 4:00 PM
15 13jason_sac26, chris_chi24, tampaLisa73 and 12 others
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