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ForumsExercise & Body CompositionCreatine kinase elevations on GLP-1 — what worked for you? Page 3

Creatine kinase elevations on GLP-1 — what worked for you?

A1cHero_PHX Thu, Apr 2, 2026 at 5:38 AM 37 replies 1,327 viewsPage 3 of 8
Dr.PainCLE
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Apr 2, 2026 at 2:56 PM#11
MASHdoc_SA said:
lean mass + resistance training is the combo.

Body composition tracking via bioimpedance on lean mass (InBody scan every 3 months):

MetricBaselineMonth 3Month 6Month 9
Skeletal Muscle (lbs)69697273
Body Fat (lbs)96835543
Body Fat %41%32%28%20%
Visceral Fat (cm²)1661218656

Note: skeletal muscle mass dipped initially then recovered with consistent resistance training + high protein. The visceral fat reduction is where the metabolic magic happens.

Last edited: Apr 2, 2026 at 5:56 PM
16 14Dr.PathRoch, mona_PHX, andrew_nyc and 13 others
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pete_nash
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Nashville, TN
Apr 2, 2026 at 6:52 PM#12
carl_compliance said:
Agreed on the ranges, with the condition that a single DEXA is not a measurement, it is one draw from a distribution.

This answered a question I did not know how to ask.

17 15Dr.Martinez, mike_mod, SarahChen_PharmD and 14 others
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dan_philly
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Philadelphia, PA
Apr 2, 2026 at 10:48 PM#13
MASHdoc_SA said:
lean mass + resistance training is the combo.

Physical therapist weighing in on lean mass. I work with bariatric and metabolic patients daily.

The resistance training evidence is critical here:

The Lundgren 2024 JAMA paper[1] showed that structured resistance training preserved 73% more lean mass in GLP-1 patients vs medication alone. When discussing lean mass, we MUST include the exercise component.

My minimum prescription: 3x/week compound movements (squat, deadlift, press, row), progressive overload, 7-10K steps/day, and 1.2-1.6g protein/kg/day.

References:
[1] Lundgren JR, et al. JAMA. 2024;331(1):38-48.
Last edited: Apr 3, 2026 at 1:48 AM
18 16SkepticalSean, Dr.CardioMD, EndoResFellow and 15 others
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bri_stats
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Apr 3, 2026 at 2:44 AM#14
A1cHero_PHX said:
I lifted three times a week throughout and still lost lean mass.

Back pain as a lean mass side effect: not from the medication itself, but from rapid body composition changes. Losing 69 lbs shifts your center of gravity and your core muscles need time to adjust.

Physical therapy has been essential. Core strengthening exercises (planks, dead bugs, bird dogs) daily for 10 minutes have eliminated my lower back pain. Your body is literally relearning how to carry itself.

19 17JessicaM_2024, TomFromTexas, mike.trainer_LA and 16 others
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mike_mod
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Apr 3, 2026 at 6:40 AM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Report rather than reply if it drifts again.

Last edited: Apr 3, 2026 at 8:40 AM
20 18PurityPaulOR, MaxMetOK, MounjBrad and 17 others
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