Dr.PulmRoch said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.
NurseAsh_DET said:The mechanism is more central than most summaries suggest.
Genuinely useful, thank you. I had the facts and not the framework. Adding it to my notes with a link back to this thread.
Dr.PulmRoch said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
This is where I part company with the consensus forming above. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.
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Shop Reference StandardsThe figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.
Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.