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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsHas anyone dealt with rybelsus real-world vs clinical trial efficacy? Page 6

Has anyone dealt with rybelsus real-world vs clinical trial efficacy?

NeuroNate Sat, Oct 19, 2024 at 12:13 AM 31 replies 2,377 viewsPage 6 of 7
NurseLeah_Nash
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Oct 25, 2024 at 11:32 PM#26

From the other side of the consultation, briefly. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

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SurmountFan_IN
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Oct 26, 2024 at 3:18 PM#27
NurseLeah_Nash said:
The useful move here is to separate what is established from what is widely repeated.

Same experience, arrived at from the opposite direction.

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Admin
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Oct 27, 2024 at 7:04 AM#28
NurseLeah_Nash said:
The useful move here is to separate what is established from what is widely repeated.

There is a second half to this that has not been said yet. Relative and absolute effects need reading together. A 20% relative reduction on a high baseline risk is a large absolute benefit; the same relative figure on a low baseline risk is a small one, and press summaries almost always quote the relative number because it is bigger.

Last edited: Oct 27, 2024 at 11:04 AM
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Dr.PathRoch
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Oct 27, 2024 at 10:49 PM#29

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

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NeuroNate
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Oct 28, 2024 at 2:34 PM#30

OP back with an update, since a thread like this is useless without one.

Follow-up: I read the paper rather than the summary and the qualifier I was missing was in the second paragraph of the results.

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