TirzTom said:If you are going to change something, change one thing and give it long enough to express itself.
Saving this. It is the first explanation that did not require me to already understand it. Adding it to my notes with a link back to this thread.
From the other side of the consultation, briefly. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.
Dr.RheumBOS said:Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…
Agreed, and the practical implication is not to over-read a single eGFR during a period of rapid loss and altered hydration. Trend, with UACR beside it.
Correct me if the detail matters more than I have assumed.
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Shop Reference StandardsDr.RheumBOS said:Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…
Coming at Dr.RheumBOS’s question from a different direction. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.
The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.